This paper presents the simulation results of a 9000 BTU/h air conditioner with some selected fluids that have been assessed for their suitability as alternatives to R22 for air conditioners. Only those refrigerants with zero Ozone Depletion Potential (ODP) are considered. The performances of 11 refrigerants were comparatively studied using the simulation software NIST Cycle_D. R134a, R290, R600, R404A, R407A, R407B, R407C, 407D, R410A, R410B, and R417A are considered in this study. The thermal performances, which are obtained with R134a and R290, are very close to those of R22. Indeed, the electric consumptions as well as the coefficient of performance are similar to those obtained with R22. The power consumptions of the unit operating with R404A, R407C, and R410A are higher in the range 22-31 % with respect of R22. For the units operating with 407A, R407B, R407D, R407E, and R410B, the electric consumptions are higher in the range 10-23%. For R600, the power consumptions are in the range 6-8%. For all the fluids, the COP is lower by 7-24 % than R22, except for R600 for which the COP is higher by 7-9%, and R134a and R290 which exhibit the same COP as R22. When considering the thermal and environmental parameters, R290 is identified as the best candidate for R22, provided the safety aspects of using R290 are addressed.