The protection of the environment and specially the ozone layer would be caused by different gaseous wasted particularly produced by the CFC’s and HCFC’s and it the important feature in the activities industrial. The application field uses ranging from domestic to industrial would be necessarily with these compounds nevertheless; we should need physical properties for desirable combination and specifically applications for these compounds substitutes which could help for this urgent timing that provides the alternatives cares and don’t harmed environment. This paper presents a new study’s conception for refrigerants. Firstly, we start by a thermodynamical and physical modeling where our forces are particularly orientated towards contribution’s methods group that could be important for this present research. The approach has been used for the equilibrium prediction of vapour-liquid and more properties such as entropy and enthalpy for systems generations using the UNIFAC models. The tests results have shown that for the quantities of the performance’s coefficient (COP) and the azeotrope’s formation detected should be necessarily for few applications and could be used in particularly for this task. It has been also demonstrated very clearly by this method’s of contribution group for the conception of new substitutes at early stages so that the work would be easily done.