Due to its chemistry, no structural adhesive system (epoxies, acrylics. etc.) is likely to offer an ideal combination of toughness, strength, moisture resistance, and ambient-temperature curing. Therefore, for effective use of adhesives in primary structures, an engineer must be able to identify adhesives that represent an optimum compromise among the different properties. In this paper, we present techniques for screening high-strength, ambient-temperature-curing adhesives for (1) moisture resistance under sustained loading and (2) fracture resistance in a way that is directly related to joint performance.