Describes the restoration of an embroidered velvet chasuble that is part of the set of vestments of the Cardinal Vanzi on exhibition at the Orvieto Cathedral Museum. The chasuble was presumably made in Florence at the end of the 15th century; the embroidery design has been attributed to Signorelli, Bartolomeo di Giovanni, and Botticelli. For identification of the methodology, preliminary investigations were carried out: graphic survey, microscopy, identification of dyes, analysis of metal threads by scanning electron microscopy (energy-dispersive spectroscopy), ultraviolet photography, radiography, and solvent testing to identify soiling. On the basis of these analyses, it was possible to remove the previous amateurish restoration which had contributed to the deterioration of the object. After dismantling the chasuble, the velvet was restored by a full cloth support consolidated with couching stitches; the embroideries were restored on a full cloth support and consolidated with stitches selected on the basis of the results of the preliminary investigation. The intervention was consistent with the visual and structural characteristics of the object and still easily identifiable and reversible.