A study was performed to evaluate the suitability of Aquazol as an adhesive for preparing remoistenable mending tissues to treat paper-based collections. Aquazol [poly (2-ethyl-2-oxazoline)] is a non-toxic, synthetic, water-soluble adhesive; it was studied because of its good adhesion strength, good retention of flexibility, and excellent reversibility. Various formulations of Aquazol-coated remoistenable tissues were prepared, using two molecular weights of Aquazol (50 and 200), in 10% and 15% weight/volume solutions, with water and alcohol as solvents. The sample remoistenable tissues were used to mend tears on historic handmade paper, newsprint, and clay-coated paper. Mended paper samples were assessed to compare adhesion strength, reversibility, and response to humid conditions. In successful formulations, reactivation of the adhesive layer occurred quickly, with very minimal water or alcohol, resulting in a suitably tacky mending tissue; upon drying the adhesion strength was comparable to that of wheat starch paste. Because so little moisture or solvent is required to reactivate the adhesive layer, Aquazol-coated mending tissues are suitable for treating water-sensitive media, coated papers, and papers prone to tide line formation.