The paper presents the possibilities offered by different non-destructive methods for in-situ examination of stone masonry, in order to obtain information on the following matters: identification of the quarry where the stone comes from, degree of stone anisotropy, determination of elasto-dynamic constants of stone, in-situ determination of compressive strength of stone and its variability, determination of structural damages, following mechanical actions on the masonry, determination of the thickness of superficial layers, damaged by aggressive actions, determination of the filling degree of joints, with mortar, determination of mortar compressive or tensile strength, information about the development of cracks at the interface between mortar and stone.