The Modular Cleaning Program (MCP) is both a computer database system and an approach to cleaning using premixed concentrates that allows the rapid prototyping of cleaning solutions. The MCP is designed to assist the conservator in refining the cleaning of artworks by allowing more cleaning options to be tested in a fast and convenient way. Because the software component works from a database of physical and chemical properties and first principles, the MCP is well positioned to incorporate this newfound understanding of acrylic paint systems into its cleaning schema. As we gain insight into the cleaning of acrylic paint, we can tailor the range of variations offered by the MCP. The special considerations that are brought to the cleaning of acrylic emulsion paints are consequences of the complexity of the paints themselves. There are numerous components in an acrylic paint film. By examining the sensitivity and susceptibility of the various additives, we can anticipate which cleaning conditions may lead to swelling or damage to the paint film and which cleaning strategies will lead to more successful outcomes. By controlling the pH and the ionic strength (as indicated by conductivity), the conservator can minimize the aqueous cleaning systems’ effect on the paint film.