In conservation of iron cultural relics, desalination is one of very important treatment. Generally, the desalination solution is alkaline. In this study, the influence of various factors, such as pH value, in alkaline desalination solutions, on the chloride specific ion electrode were examined. These experiments showed that the pH value of the desalination solution affects the potential of chloride specific ion electrode, especially when the chloride ion concentration is low. The optimal pH of the solution is between 2 and 7. The surfactant in the solution had no significant impact on the chloride specific ion electrode, as seen in the fact that the potential value of the 1# chloride standard solution (0.5 mol/L NaOH+1.5[percent] DP-105) was equal of that of 2# solution (0.5 mol/L NaOH). However, both of them were higher than the potential value of 3# solution (aqueous solution). In practice, the components of chloride ion standard solution should be the same as that of the solution to be tested. Using chloride ion standard solutions, it was showed that when chloride ion concentration is between 0 and 200 mg/L, the standard curve was highly linear, reproducible, and precise, and had a high correlation coefficient.