A systematic study of the effects of Nd:YAG laser energy, at three wavelengths (1064, 532, and 355 nm) and Er:YAG laser at 2940 nm, on different epoxy resins and epoxy systems was performed. The tests on the study of the effect of laser energy on epoxy resins had two major goals. One focused on the influence that lasers may have during a cleaning process of art objects that contain epoxy resins. The other aim was to investigate possibilities for using lasers to remove epoxy resins from art objects. Two epoxy resins, Hxtal NYL-1 (clear) and Araldite AY103 with hardener HY991 (slightly yellow), were prepared as pure films as well as in mixtures with chalk, titanium white, microballoons, and charcoal. These materials were applied to different stone, ceramic, and glass substrates. Evaluations of the results were made with a combination of surface science and visual examination. The tests have shown that at least at high laser energy all the tested wavelengths of laser light had visual effects on both epoxy resins, which were primarily visible as discolorations and etched surfaces. Different wavelengths initiated different material alterations, for example, variations in the color of the alteration products. Additional to the laser wavelength, the characteristic of each of the components of the material irradiated influenced the laser induced reaction.