As part of a major expansion and renovation of its research, teaching, and programming spaces and services, the Museum of Anthropology at the University of British Columbia is conducting an assessment of its collection to determine the level and extent of pesticide contamination. This Pesticide Residue Project has three main components: testing of high-risk objects in the collection; determination of health and safety guidelines for continued handling and use; and consultation with originating communities. This article looks at the project’s original objectives and results to date.