Growth of mixed cultures of a fungus, a cyanobacterium, and an alga on samples of methyl tri-methoxy silane (MTMOS) were run. After six months samples were examined visually, with SEM, and by FTIR for evidence of microbiological attack. MTMOS did not support growth of test microorganisms. Comparison of controls with experimentals showed little visual or SEM evidence for biological attack. FTIR analysis showed no evidence of changes in the bond structure between control and experimental tests. It was concluded that the use of MTMOS in the consolidation of a dolostone monument in the Metropolitan Museum of Art's collection will not encourage the growth and spread of the deleterious effects of the microorganisms currently in the stone.