This project investigates the materials and techniques used by Tibetan artists. Six Tibetan thangkas were analyzed by infrared reflectography, energy dispersive x-ray fluorescence, Fourier transform infrared microspectroscopy, Raman spectroscopy, scanning electron microscopy-energy dispersive spectroscopy, and high-performance liquid chroma-tography. The analysis has suggested that three thangkas of the eighteenth - nineteenth century have a traditional palette, which includes azurite, vermilion, orpiment, bronchantite, red lead, dolomite, magnesite, organic red with calcite or magnesite substrate, and alumino-silicate clay minerals. Another late nineteenth or early twentieth century thangka shows the use of Western pigments such as emerald green, ultramarine, calcite, gypsum, chrome yellow, gold color from brass powder, and red and yellow dyes with barium sulfate substrates. Two twentieth century thangkas made for the tourist trade revealed a twentieth century palette such as titanium dioxide, phthalocyanine blue, phthalocyanine green, and other pigments such as red lead, chrome yellow, barium sulfate, and gypsum.