In order to prepare a fungicide used for antiquities protection in bad surroundings, N, N-di-octyl-3, 3-dithiodropinamide is halogenated and cyclized with such reactants as chlorine to acrude reaction mixture containing 2-n-octyl-4lisothiazolone hydrohalide salt in solution. The hydrohalide salt is crystallized isolated and then hydrolyzed with water to the desired isothiazolone (70% yield). The Huake-108 is achieved when the isothiazolone is mixed with a special solution. The best production condition is obtained from the experiments, and the useful analytic method is derived. When it is used at the excavation spot of the Yangling Mausoleum, the Huake-108 has excellent fungicide effect, and good adaptability can be seen. It can provide benefical results for similar conditions. -- ICCROM