There are many garments in the market that are promoted to have temperature regulating properties. For example, some garments have claims to make the wearer feel cooler while exercising. For cooler environments, some garments are claimed to have warmth without excessive weight. However, it is often difficult to substantiate these claims. A study was initiated to obtain an understanding of the validity of such claims, and then to develop cotton garments that really work for temperature regulation. Several treatments were applied using padding, coating, or other techniques to cotton-rich fabrics with the goal of achieving temperature regulation. These fabrics were then evaluated using both standard and custom protocols. Limited wear testing was also conducted for comparison to the data from these studies. The results of this study will be discussed.