Smart garments can make an enormous contribution to health care. Designed and fabricated properly they can increase patient safety and comfort and replace bulky medical instrumentation. Computer aided 3D knitting is a mass customizable form of manufacturing already in use in the garment industry. Formfitting seamless garments can be constructed with specialized yarns to perform specific functions. Using Shima Seiki CAD system and knitting machine, we are researching knit architecture and its potential for modular and flexible production for a variety of medical applications. This mode of fabrication offers a future of many opportunities for smart garments and holds remarkable potential for innovative customizable design solutions in medical apparel.