Because of severe weathering, the surface of some historic stones are in great danger. The surface-protective materials used in the past do not meet the requirements of conservators. It is a crucial task to develop new consolidating agents for soft stone surfaces. Certain crude biomimetic materials have performed well in terms of the resistance to ageing and great compatibility to stone matrixes; thus they are suitable materials for consolidation of historic stones that are in danger due to weathering. In this research, solutions of various biomacromolecules were selected as controlling templates. Super-saturated solution of calcium oxalate, apatite and calcium carbonate were applied on replicas of weathering stone at room temperature. The crystallization of these salts on the stone surface and cracks was controlled and their consolidation performances were evaluated in terms of, anti-compressive strength, surface hardness and water resistance. The results showed that the biomimetic materials prepared by biomimetic methods can consolidate the replicas of weathering stone. Among the biomimetic materials investigated, the consolidation strength of apatite is the highest and the consolidation performance of chondroitin sulfate is the best. Furthermore, of the three consolidation methods, the greatest specimen strength was achieved by direct mixing, but the highest water resistance was obtained through surface penetration of the specimen. Stone consolidation by biomimetic approach represents a new category of consolidation.