To better understand the development of sacrificial red glazes during the Ming and Qing Dynasties, the chemical compositions of 10 pieces of Yongle sacrificial red glaze porcelains in Ming Dynasty were determined using the micro-probe EDXRF. Combined with previously published data, the sacrificial red glazes and bodies made during Ming and Qing Dynasties were compared. Results showed that the mean values of RO + R2O (wt% ), in the sacrificial red glaze from Yongle, Xuande, and Wanli porcelains of the Ming Dynasty were 20% lower than that in the Kangxi, Yongzheng, and Qianlong porcelains of the Qing Dynasty, whereas its mean value of RO/R20 (mol/mol) was 45% less and the mean value of R02/R2O3 (mol/mol) was 34% higher. The RO2 (mol) values of Yongle, Xuande, and Wanli porcelains of the Ming Dynasty were all above 5. 8 but these of Qing Dynasty ones were all below 5.4. The changes in chemical composition suggest that the process for making the sacrificial red glaze in the Ming Dynasty was lost and a new process was created in the Qing Dynasty.