Solid-phase microextraction (SPME) in combination with gas chromatography/mass spectroscopy (GC/MS) analysis offers a simple and sensitive option for analyzing objects that have been contaminated with volatile and semi-volatile organic pesticides. In this project, items from the National Museum of the American Indian (NMAI) were placed in plastic bags and allowed to sit overnight. A SPME fiber was then inserted into the bag, exposed for approximately one hour, and analyzed by GC/MS. Naphthalene and paradichlorobenzene were found on several objects. It may also be possible to detect other semi-volatile pesticides. A privately owned piece of reproduction trade cloth was studied more extensively to evaluate equilibrium times and reproducibility. Raising the humidity within the bag substantially increased the release of pesticides from the cloth. This preliminary project demonstrated that this simple setup is practical. Its ease of use and minimal effect on the object make it attractive to museum staff and may make it more attractive to Native constituents who have concerns beyond preserving the physical material of the object. Quantitative analysis appears feasible but will require further study.