It is defended in this paper that the Roman epigraphy awed the Quattrocento’s artists and particularly those who were interested in creating an alphabet. By taking a closer look at the Trajan’s Column, especially at the inscriptions found on the pedestal, we wished to discover whether this monument was in fact used as a referent by those typographers, humanists, printers, artists and editors. To accomplish this objective, we compared it with other tracings taken from the marble frame of the Holy Tomb of the Capilla Rucelai, by Leon Battista Alberti, by means of a thorough tracing of this alphabet. Finding similarities in composition criteria might be the key for ratifying the model that the Ancient World experienced in the Quatroccento.